Ammonium Chloride → Tert-butyl 4-ethynyl-4-hydroxypiperidine-1-carboxylate

A solution of ethynylmagnesium chloride in THF (100 mL, 50 mmol) was diluted with THF (50 mL) and cooled in an ice—water bath. A solution of Boc-4-piperidone (5.06 g, 25.4 mmol) (Aldrich) in THF (50 mL) was added dropwise over 15 min. The mixture was stirred with cooling for 3 h. Aqueous ammonium chloride solution (100 mL, 15% W/V) was then added and the resulting mixture extracted with ether (2×200 mL). The ether layers were washed with saturated aqueous sodium chloride solution (200 mL), then combined, dried (MgSO4), filtered and concentrated. The residue was purified by chromatography (Biotage 40M, ethyl acetate—hexanes 1:3, V/V as solvent) to give N-Boc-4-hydroxy-4-ethynyl-piperidine as a colorless oil that solidified on standing. (Yield 5.39 g, 94.2%).

1. temperaturecooled in an ice—water bath
2. temperaturewith cooling for 3 h
3. extractionthe resulting mixture extracted with ether (2×200 mL)
4. washThe ether layers were washed with saturated aqueous sodium chloride solution (200 mL)
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. concentrationconcentrated
8. customThe residue was purified by chromatography (Biotage 40M, ethyl acetate—hexanes 1:3, V/V as solvent)

ORD record

ord-5e67fda0fedb4662ada85ddc51947b0b

Source dataset

uspto-grants-2001_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06252086B1