HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxide → ((p-(2-Methoxyethyl)phenoxy)methyl)oxirane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxide | HCID 961 | — |
| Reactant | Phenol | HCID 996 | — |
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | 4-(2-Methoxyethyl)phenol | HCID 92516 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Potassium | HCID 5462222 | — |
| Solvent | Water | HCID 962 | — |
| Product | ((p-(2-Methoxyethyl)phenoxy)methyl)oxirane | HCID 92515 | — |
Reaction Steps
p-(2-Methoxyethyl)phenol (A) and epichlorohydrin (B, 1.4-2.0 eqv.) are reacted in water, at least 1.5 kg, preferably about 2 kg of water per kg of phenol, during the addition of sodium (or potassium) hydroxide solution, (1.3-1.7 eqv.) to form 1-(2,3-epoxypropoxy)-4-(2-methoxyethyl)benzene; (p-methoxyethyl-epoxypropoxybenzene). The reaction is preferably performed at a temperature of 50-70° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06252113B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-a2f92e52b6434a5db8407b696d297171 |
| Source note | uspto-grants-2001_06 |