Potassium Carbonate → HCID 22568804, compound

HRID 1069994Notes

Reaction equation

HRID 1069994 reaction equation
[CH3:1][C:2]1[CH:13]=[C:12]([C:14]#[C:15][Si](C)(C)C)[CH:11]=[CH:10][C:3]=1[CH2:4][N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1.C(=O)([O-])[O-].[K+].[K+]>CO>[C:14]([C:12]1[CH:11]=[CH:10][C:3]([CH2:4][N:5]2[CH:9]=[CH:8][N:7]=[CH:6]2)=[C:2]([CH3:1])[CH:13]=1)#[CH:15]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 225689641-(2-Methyl-4-trimethylsilanylethynyl-benzyl)-1H-imidazole

Product 1

HCID 22568804HCID 22568804, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; I-(2-methyl-4-trimethylsilanylethynyl-benzyl)-1H-imidazole (Intermediate 140, 140.0 mg, 0.53 mmols) in methanol (5 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (105 mg, 100%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-2343356ac9f34d8da30696d244eb7981
Source dataset
uspto-grants-2001_06
Patent number
US06252090B1

Reaction notes

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