Methanol → 4-[2-(1-Pyrrolidinyl)ethoxy]phenyl 2-[4-[3-(1-Pyrrolidinyl)propoxy]phenyl]benzo[b]thiophen-3-yl Ketone Dioxalate

HRID 1070318노트

반응식

HRID 1070318 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[CH:10]=2)=[CH:5][CH:4]=1.Cl.[N:19]1([CH2:24][CH2:25][O:26][C:27]2[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)[CH2:23][CH2:22][CH2:21][CH2:20]1.[CH3:36][OH:37]>C(Cl)Cl>[C:31]([OH:33])(=[O:32])[C:36]([OH:2])=[O:37].[C:31]([OH:33])(=[O:32])[C:36]([OH:2])=[O:37].[N:19]1([CH2:24][CH2:25][CH2:1][O:2][C:3]2[CH:8]=[CH:7][C:6]([C:9]3[S:13][C:12]4[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=4[C:10]=3[C:31]([C:30]3[CH:29]=[CH:28][C:27]([O:26][CH2:25][CH2:24][N:19]4[CH2:20][CH2:21][CH2:22][CH2:23]4)=[CH:35][CH:34]=3)=[O:33])=[CH:5][CH:4]=2)[CH2:23][CH2:22][CH2:21][CH2:20]1

참가 물질

5

반응물 3

HCID 887MethanolHCID 41373912-(4-methoxyphenyl)benzothiopheneHCID 131748684-(2-Pyrrolidin-1-ylethoxy)benzoic acid hydrochloride

생성물 1

HCID 867570814-[2-(1-Pyrrolidinyl)ethoxy]phenyl 2-[4-[3-(1-Pyrrolidinyl)propoxy]phenyl]benzo[b]thiophen-3-yl Ketone Dioxalate수율 59%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

By essentially following the procedure detailed in Example 1, Part C, the title compound was prepared from 2-(4-methoxyphenyl)benzo[b]thiophene (Example 3, Part A) and 4-[2-(1-pyrrolidinyl)ethoxy]benzoic acid hydrochloride in 59% yield as an oil following radial chromatography (SiO2; gradient of 2-5% MeOH in CH2Cl2).

출처 및 근거

ORD 기록
ord-c5a892e54e9c4db3bbef8f12292e3728
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06251921B1

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