HRID1070318

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

HCID4137391

2-(4-methoxyphenyl)benzothiophene

C15H12OS

HCID13174868

4-[2-(Pyrrolidin-1-yl)ethoxy]benzoic acid--hydrogen chloride (1/1)

C13H18ClNO3

PRODUCTS

生成物

结构：O=C(O)C(=O)O.O=C(O)C(=O)O.O=C(c1ccc(OCCN2CCCC2)cc1)c1c(-c2ccc(OCCCN3CCCC3)cc2)sc2ccccc12

HCID86757081

未命名化合物

收率 59%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

By essentially following the procedure detailed in Example 1, Part C, the title compound was prepared from 2-(4-methoxyphenyl)benzo[b]thiophene (Example 3, Part A) and 4-[2-(1-pyrrolidinyl)ethoxy]benzoic acid hydrochloride in 59% yield as an oil following radial chromatography (SiO2; gradient of 2-5% MeOH in CH2Cl2).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c5a892e54e9c4db3bbef8f12292e3728
来源数据集: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06251921B1
来源说明: uspto-grants-2001_06

反应 SMILES

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[CH:10]=2)=[CH:5][CH:4]=1.Cl.[N:19]1([CH2:24][CH2:25][O:26][C:27]2[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)[CH2:23][CH2:22][CH2:21][CH2:20]1.[CH3:36][OH:37]>C(Cl)Cl>[C:31]([OH:33])(=[O:32])[C:36]([OH:2])=[O:37].[C:31]([OH:33])(=[O:32])[C:36]([OH:2])=[O:37].[N:19]1([CH2:24][CH2:25][CH2:1][O:2][C:3]2[CH:8]=[CH:7][C:6]([C:9]3[S:13][C:12]4[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=4[C:10]=3[C:31]([C:30]3[CH:29]=[CH:28][C:27]([O:26][CH2:25][CH2:24][N:19]4[CH2:20][CH2:21][CH2:22][CH2:23]4)=[CH:35][CH:34]=3)=[O:33])=[CH:5][CH:4]=2)[CH2:23][CH2:22][CH2:21][CH2:20]1