化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → 4-[2-(1-Pyrrolidinyl)ethoxy]phenyl 2-[4-[3-(1-Pyrrolidinyl)propoxy]phenyl]benzo[b]thiophen-3-yl Ketone Dioxalate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 2-(4-Methoxyphenyl)benzothiophene | HCID 4137391 | — |
| 反応物 | 4-(2-Pyrrolidin-1-ylethoxy)benzoic acid hydrochloride | HCID 13174868 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-[2-(1-Pyrrolidinyl)ethoxy]phenyl 2-[4-[3-(1-Pyrrolidinyl)propoxy]phenyl]benzo[b]thiophen-3-yl Ketone Dioxalate | HCID 86757081 | 59% |
反応手順
By essentially following the procedure detailed in Example 1, Part C, the title compound was prepared from 2-(4-methoxyphenyl)benzo[b]thiophene (Example 3, Part A) and 4-[2-(1-pyrrolidinyl)ethoxy]benzoic acid hydrochloride in 59% yield as an oil following radial chromatography (SiO2; gradient of 2-5% MeOH in CH2Cl2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06251921B1 |
| 出典データセット | uspto-grants-2001_06 |
| ORD ID | ord-c5a892e54e9c4db3bbef8f12292e3728 |
| 出典メモ | uspto-grants-2001_06 |