Ammonia → 4-chloro-5-(trifluoromethyl)-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one

HRID 107035Notes

Reaction equation

HRID 107035 reaction equation
[CH:20]([OH:21])([CH3:22])[CH3:23].[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]([Cl:18])[c:7]1[CH:8]([CH2:9][C:10](=[O:11])[O:12][CH3:13])[C:14]([F:15])([F:16])[F:17].[NH3:19].[OH2:24]>>[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]2[c:7]1[CH:8]([C:14]([F:15])([F:16])[F:17])[CH2:9][C:10](=[O:11])[NH:19]2

Participants

5

Reactant 4

HCID 222AmmoniaHCID 962WaterHCID 3776IsopropanolHCID 86666569Methyl 3-(4,6-dichloropyrimidin-5-yl)-4,4,4-trifluorobutanoate

Product 1

HCID 866665794-chloro-5-(trifluoromethyl)-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one

Sources & evidence

ORD record
ord-8fa139e840af467ab6f73252d86c2926
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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