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Into a 1 liter flask 600 ml of dried Ethanol and 91.89 g (0.51 mol) of Guanidine Carbonate and 146.1 g (1.11 mol) of ethyl acetoacetate were added. The reaction solution was gradually heated to reflux temperature and stirred overnight. 300 ml of Ethanol was evaporated and reaction solution was heated under reflux for two hours. After cooling, 300 ml of Hexane was added. Deposit was filtered, washed and dried. 119.3 g of 6-methylisocytosine was obtained.

1. temperatureThe reaction solution was gradually heated
2. temperatureto reflux temperature
3. custom300 ml of Ethanol was evaporated
4. customreaction solution
5. temperaturewas heated
6. temperatureunder reflux for two hours
7. temperatureAfter cooling
8. filtrationDeposit was filtered
9. washwashed
10. customdried