Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Aminobicyclo(2,2,1)heptane-2-carboxylic acid | HCID 115288 | — |
| Product | HCID 67101682 | HCID 67101682 | 92% |
Reaction Steps
To 25 mL of methanol at 0° C. was added thionyl chloride (2.4 mL, 32 mmol). After stirring at 0° C. for 5 min, 2-amino-2-norbornanecarboxylic acid (1.0 g, 6.4 mmol) was added in one portion, and the mixture was heated at reflux for 16 h. The mixture was concentrated to give the product (1.2 g, 92%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06903075B1 |
|---|
| Source dataset | uspto-grants-2005_06 |
|---|
| ORD ID | ord-d6a2dec377e94b3fa11f6c1ab139212d |
|---|
| Source note | uspto-grants-2005_06 |
|---|
