Methanol → HCID 67101682, compound

HRID 1070438Notes

Reaction equation

HRID 1070438 reaction equation
S(Cl)([Cl:3])=O.[NH2:5][C:6]1([C:13]([OH:15])=[O:14])[CH2:11][CH:10]2[CH2:12][CH:7]1[CH2:8][CH2:9]2.[CH3:16]O>>[ClH:3].[NH2:5][C:6]1([C:13]([O:15][CH3:16])=[O:14])[CH2:11][CH:10]2[CH2:12][CH:7]1[CH2:8][CH2:9]2

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 1152882-Aminobicyclo(2,2,1)heptane-2-carboxylic acid

Product 1

HCID 67101682HCID 67101682, compoundYield 92%

Conditions

Temperature
0 °C

Procedure

To 25 mL of methanol at 0° C. was added thionyl chloride (2.4 mL, 32 mmol). After stirring at 0° C. for 5 min, 2-amino-2-norbornanecarboxylic acid (1.0 g, 6.4 mmol) was added in one portion, and the mixture was heated at reflux for 16 h. The mixture was concentrated to give the product (1.2 g, 92%) as a white solid.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 16 h
  3. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-d6a2dec377e94b3fa11f6c1ab139212d
Source dataset
uspto-grants-2005_06
Patent number
US06903075B1

Reaction notes

Loading…