Hydrochloric Acid → HCID 69276408, compound

HRID 1070491Notes

Reaction equation

HRID 1070491 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][CH:11]1[CH2:16][CH2:15][N:14](C(OCC)=O)[CH2:13][CH2:12]1.[ClH:22]>>[ClH:22].[ClH:22].[NH:14]1[CH2:13][CH2:12][CH:11]([NH:10][C:2]2[NH:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N:3]=2)[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 30184551-Piperidinecarboxylic acid, 4-(1H-benzimidazol-2-ylamino)-, ethyl ester

Product 1

HCID 69276408HCID 69276408, compound

Procedure

The product from step (i) (0.58 g) was heated under reflux with 5M hydrochloric acid (20 ml) for 24 h. The solvent was evaporated under reduced pressure, the residue azetroped with toluene, washed with ether. Yield 0.58 g as a solid.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue azetroped with toluene, washed with ether

Sources & evidence

ORD record
ord-970edff048354f7e89832a449a963aaf
Source dataset
uspto-grants-2005_06
Patent number
US06903085B1

Reaction notes

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