HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxymethylpyridine → N-(4-Chlorophenyl)-4-[(pyridin-4-yl)methoxy]phthalazin-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxymethylpyridine | HCID 11472 | — |
| Reactant | 1-Chloro-4-(4-chlorophenylamino)-phthalazine | HCID 12075649 | — |
| Solvent | Propan-2-one--dichloromethane (1/1) | HCID 21584124 | — |
| Product | N-(4-Chlorophenyl)-4-[(pyridin-4-yl)methoxy]phthalazin-1-amine | HCID 22397275 | 87% |
Reaction Steps
The general procedure used for the preparation of Example 3 was used in step 1 of the preparation of Example 4 from 1-chloro-4-(4-chlorophenylamino)phthalazine and 4-pyridyl-carbinol; (87% yield). TLC (20% acetone/dichloromethane): Rf=0.26.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06903101B1 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-b3d2736de81044a7a0a56909c79d6db3 |
| Source note | uspto-grants-2005_06 |