Cyclopentylamine → HCID 22397343, compound

HRID 1070559Notes

Reaction equation

HRID 1070559 reaction equation
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].[CH:8]1([NH2:13])[CH2:12][CH2:11][CH2:10][CH2:9]1.[CH:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]>C(OCC)(=O)C.CCCCCCC>[C:17]([O:16][C:14]([N:13]([CH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)[CH2:3][CH2:2][C:1]([O:5][CH2:6][CH3:7])=[O:4])=[O:15])([CH3:20])([CH3:19])[CH3:18]

Participants

5

Reactant 3

HCID 2906CyclopentylamineHCID 8821Ethyl AcrylateHCID 61207tert-Butyl Formate

Product 1

HCID 22397343HCID 22397343, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from ethyl acrylate (1.09 ml, 10 mmol) and cyclopentylamine (0.99 ml, 10 mmol) according to Example 2a. Yield: 2.28 g (80%). ESI-MS: 286.2 (M+H)+, 230.2 (M+H—C4H8)+, 186.2 (M+H-Boc)+. Rf (silica gel; ethyl acetate/heptane, 1:4, v/v): 0.45.

Sources & evidence

ORD record
ord-a41eaad80fbb4567b8d9fd53622c09f7
Source dataset
uspto-grants-2005_06
Patent number
US06903107B1

Reaction notes

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