HRID1070567

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCOC(=O)Nc1nccc2cc(OCC[C@@H]3CCCCN3C(=O)OC(C)(C)C)ccc12

HCID20794986

未命名化合物

结构：CC(C)(C)C(C[C@H](NC1CCCCCCC1)C(=O)O)C(=O)O

HCID20794995

未命名化合物

PRODUCTS

生成物

结构：C=CCOC(=O)Nc1nccc2cc(OCCC3CCCCN3C(=O)[C@H](CC(C(=O)O)C(C)(C)C)NC3CCCCCCC3)ccc12

HCID20794977

未命名化合物

收率 58%

PROCEDURE

实验过程

N-Cyclooctyl-γ-tert-butyl-L-glutamic acid (8a, 344 mg, 1.1 mmol) and 2-(2-(1-allyloxycarbonylamino-isoquinolin-6-oxy)-ethyl)-piperidine (1g, 391 mg, 1.1 mmol) were coupled, using the methodology described in Example 1i, providing 380 mg (58%) of the title compound as a colourless oil. ESI-MS: 651.3 (M+H)+. Rf (silica gel; dichloromethane/methanol, 9:1, v/v): 0.23.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eb3c6f24aac54ee98e6130be4c9011d4
来源数据集: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06903107B1
来源说明: uspto-grants-2005_06

反应 SMILES

[CH:1]1([NH:9][C@H:10]([C:20]([OH:22])=O)[CH2:11][CH:12]([C:16]([CH3:19])([CH3:18])[CH3:17])[C:13]([OH:15])=[O:14])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(OC([N:30]1[CH2:35][CH2:34][CH2:33][CH2:32][C@H:31]1[CH2:36][CH2:37][O:38][C:39]1[CH:40]=[C:41]2[C:46](=[CH:47][CH:48]=1)[C:45]([NH:49][C:50]([O:52][CH2:53][CH:54]=[CH2:55])=[O:51])=[N:44][CH:43]=[CH:42]2)=O)(C)(C)C>>[CH:1]1([NH:9][C@H:10]([C:20]([N:30]2[CH2:35][CH2:34][CH2:33][CH2:32][CH:31]2[CH2:36][CH2:37][O:38][C:39]2[CH:40]=[C:41]3[C:46](=[CH:47][CH:48]=2)[C:45]([NH:49][C:50]([O:52][CH2:53][CH:54]=[CH2:55])=[O:51])=[N:44][CH:43]=[CH:42]3)=[O:22])[CH2:11][CH:12]([C:16]([CH3:17])([CH3:18])[CH3:19])[C:13](=[O:14])[OH:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1