(2S)-1-tert-butoxycarbonyl-2(2-(1-allyloxycarbonylamino-isoquinolin-6-oxy)ethyl)-piperidine → 1-(N-cyclooctyl-gamma-tert-butyl-L-glutamyl)-2-(2-(1-allyloxycarbonylamino-isoquinolin-6-oxy)-ethyl)-piperidine

Participants

Reaction Steps

N-Cyclooctyl-γ-tert-butyl-L-glutamic acid (8a, 344 mg, 1.1 mmol) and 2-(2-(1-allyloxycarbonylamino-isoquinolin-6-oxy)-ethyl)-piperidine (1g, 391 mg, 1.1 mmol) were coupled, using the methodology described in Example 1i, providing 380 mg (58%) of the title compound as a colourless oil. ESI-MS: 651.3 (M+H)+. Rf (silica gel; dichloromethane/methanol, 9:1, v/v): 0.23.

Provenance & Evidence