反应详情

A solution of 2,2,6,6-tetramethyl-4-piperidone monohydrate (40 g, 23.1 mmol) and methyl iodide (98.31 g, 69.3 mmol) in isopropyl alcohol (25 mL) was stirred at RT for 48 hours. The resulting suspension was filtered, the solid residue was dried and recrystallized from MeOH. After filtration and repeated washings with MeOH the solid was dried giving pure title compound (31.6 g, 10.6 mmol, yield 46.0%) as pale brown crystals.

1. filtrationThe resulting suspension was filtered
2. customthe solid residue was dried
3. customrecrystallized from MeOH
4. filtrationAfter filtration
5. washwashings with MeOH the solid
6. customwas dried