1,1'-Carbonyldiimidazole → HCID 68503878, compound

HRID 1070748Notes

Reaction equation

HRID 1070748 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][C:9]([OH:11])=O)[CH:2]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[CH:24]1([N:34]2[CH2:39][CH2:38][N:37]([CH2:40][CH2:41][CH2:42][CH2:43][NH2:44])[CH2:36][CH2:35]2)[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27][CH2:26][CH2:25]1>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][C:9]([NH:44][CH2:43][CH2:42][CH2:41][CH2:40][N:37]2[CH2:38][CH2:39][N:34]([CH:24]3[C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH2:27][CH2:26][CH2:25]3)[CH2:35][CH2:36]2)=[O:11])[CH:2]=1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 1019843-(3-Pyridinyl)-2-propenoic acidHCID 69687501HCID 69687501, compound

Product 1

HCID 68503878HCID 68503878, compound

Procedure

Batch size: 2.7 g (18 mmol) 3-(3-pyridyl)-acrylic acid, 3.15 g (19 mmol) CDI and 5.0 g (17.4 mmol) 4-[4-(1,2,3,4-tetrahydro-naphthalin-1-yl)-piperazin-1-yl]-butylamine.

Sources & evidence

ORD record
ord-7de8586d366042ba8aaf6a6b80ebab36
Source dataset
uspto-grants-2005_06
Patent number
US06903118B1

Reaction notes

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