2-Naphthalenesulfonyl chloride → HCID 77692401, compound

HRID 1070751Notes

Reaction equation

HRID 1070751 reaction equation
[N:1]1([CH2:7][CH2:8][NH:9][C:10](=[O:19])[CH:11]=[CH:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][C:21]=1[S:30](Cl)(=[O:32])=[O:31]>ClCCl>[CH:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][C:21]=1[S:30]([N:4]1[CH2:5][CH2:6][N:1]([CH2:7][CH2:8][NH:9][C:10](=[O:19])[CH:11]=[CH:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[CH2:2][CH2:3]1)(=[O:31])=[O:32]

Participants

4

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 57010858HCID 57010858, compound

Product 1

HCID 77692401HCID 77692401, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Batch size: 8.0 g (22.6 mmol) N-(2-(piperazin-1-yl)-ethyl]-3-pyridin-3-yl-acrylamide.trihydrochloride (substance 317 as a trihydrochloride), 13 ml (92.7 mmol) TEA and 5.6 g (24.9 mmol) naphthalin-2-sulfonic acid chloride in 180 ml absolute dichloromethane.

Sources & evidence

ORD record
ord-05e5e0aef4e34f259bdab9b825029ad7
Source dataset
uspto-grants-2005_06
Patent number
US06903118B1

Reaction notes

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