Hydrazine hydrate (1:1) → HCID 69687501, compound

HRID 1070767Notes

Reaction equation

HRID 1070767 reaction equation
Cl.Cl.[CH:3]1([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][CH2:22][N:23]3C(=O)C4C(=CC=CC=4)C3=O)[CH2:15][CH2:14]2)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4]1.O.NN>C(O)C>[CH:3]1([N:13]2[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][CH2:21][CH2:22][NH2:23])[CH2:17][CH2:18]2)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 69688966HCID 69688966, compound

Product 1

HCID 69687501HCID 69687501, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Batch size: 52 g (106 mmol) 2-{4-[4-(1,2,3,4-tetrahydronaphthalin-1-yl)-piperazin-1-yl]-butyl}-isoindolin-1,3-dione-dihydrochloride and 14.6 ml (300 mmol) hydrazine-hydrate in 500 ml ethanol.

Sources & evidence

ORD record
ord-97df515c3c7b4086a00de6a6bb564f6b
Source dataset
uspto-grants-2005_06
Patent number
US06903118B1

Reaction notes

Loading…