Lithium Hydroxide → 6-[[1-Phenyl-2-(phenylmethanesulfonyl)-1H-benzimidazol-6-yl]oxy]Hexanoic Acid

HRID 1070878Notes

Reaction equation

HRID 1070878 reaction equation
C[O:2][C:3](=[O:35])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[C:16]([S:18]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)(=[O:20])=[O:19])[N:15]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[C:14]=2[CH:34]=1.[OH-].[Li+]>>[C:28]1([N:15]2[C:14]3[CH:34]=[C:10]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:35])=[O:2])[CH:11]=[CH:12][C:13]=3[N:17]=[C:16]2[S:18]([CH2:21][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)(=[O:19])=[O:20])[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 101635726-[[1-Phenyl-2-(phenylmethanesulfonyl)-1H-benzimidazol-6-yl]oxy]Hexanoic Acid Methyl Ester

Product 1

HCID 101627216-[[1-Phenyl-2-(phenylmethanesulfonyl)-1H-benzimidazol-6-yl]oxy]Hexanoic Acid

Procedure

175 mg of 6-[[1-phenyl-2-(phenylmethanesulfonyl)-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester was reacted with lithium hydroxide according to general operating instructions 3. 143 mg was obtained.

Workup

  1. custom143 mg was obtained

Sources & evidence

ORD record
ord-17aacf09a8274407934734fcb6501804
Source dataset
uspto-grants-2005_06
Patent number
US06903126B2

Reaction notes

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