関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | N-Hydroxysuccinimide | HCID 80170 | — |
| 反応物 | 16-Hydroxyicosa-2,4,6,8-tetraenoic acid | HCID 53764727 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (5Z,8Z,11Z,14Z)-16-Hydroxy-5,8,11,14-eicosatetraenoic acid | HCID 6442739 | 75% |
反応手順
An equimolar mixture of 16-hydroxyeicosatetraenoic acid (16 HETE) and N-hydroxysuccinimide in anhydrous tetrahydrofuran (THF) was cooled to 0° C. To this was added 1 equivalent of dicyclohexylcarbodiimide (DCC) with stirring. After 12 h at room temperature, the solvent was removed in vacuo and the residue was purified by SiO2 chromatography to afford the corresponding 16-HETE N-hydroxysuccimide ester in 75% yield as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06903135B2 |
|---|
| 出典データセット | uspto-grants-2005_06 |
|---|
| ORD ID | ord-700a7a9a569e49a0b5d3f44cb2894c6b |
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| 出典メモ | uspto-grants-2005_06 |
|---|
