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HRID1070903

反应详情

EQUATION

反应方程式

HRID 1070903 的结构方程式

REACTANTS

反应物

1
结构：CCOC(=O)[C@H]1CCCN1C(=O)CCCCC(=O)N1CCC[C@@H]1C(=O)OCc1ccccc1
HCID69461827

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)[C@H]1CCCN1C(=O)CCCCC(=O)N1CCC[C@@H]1C(=O)O
HCID20795496

未命名化合物

收率 95%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

A mixture of 92 mg (0.2 mmol) (R)-1-[6-[(R)-2-ethoxycarbonyl-pyrrolidin-1-yl]-6-oxo-hexanoyl]-pyrrolidine-2-carboxylic acid benzyl ester and 30 mg 10% palladium/carbon in 5 ml ethylacetate was hydrogenated over night. Filtration and removal of the solvent yielded 70 mg (R)-1-[6[(R)-2-ethoxycarbonyl-pyrrolidin-1-yl]-6-oxo-hexanoyl]-pyrrolidine-2-carboxylic acid as a light yellow oil, MS m/e (%): 369 (M+H+, 100).

WORKUP

后处理

  1. waitwas hydrogenated over night
  2. filtrationFiltration and removal of the solvent