反应详情

To 230 mmol of lithium aluminum hydride in 800 ml of THF, under a nitrogen atmosphere, are added 180 mmol of cis-2-benzyl-7-methoxy-1,3,3a,9b-tetrahydrobenzopyrano[3,4-c]pyrrol-4-one, described in Preparation G, at +5° C. The reaction medium is maintained at +10° C. for one hour before being hydrolyzed, and is filtered on Celite. The organic phase is dried and, after evaporation, gives the expected product.

1. customdescribed in Preparation G, at +5° C
2. temperatureThe reaction medium is maintained at +10° C. for one hour
3. filtrationis filtered on Celite
4. customThe organic phase is dried
5. customafter evaporation