Triethylamine → 4-amino-N-(3-hydroxy-2,2-dimethyl-propyl)benzenesulfonamide

HRID 1071356노트

반응식

HRID 1071356 반응식
[S:1](F)(=[O:10])([C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1)=[O:2].[NH2:12][CH2:13][C:14]([CH3:18])([CH3:17])[CH2:15][OH:16].C(N(CC)CC)C>C(O)CCC>[OH:16][CH2:15][C:14]([CH3:18])([CH3:17])[CH2:13][NH:12][S:1]([C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1)(=[O:10])=[O:2]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 668234-Aminobenzenesulfonyl fluorideHCID 1173261-Propanol, 3-amino-2,2-dimethyl-

생성물 1

HCID 219562104-amino-N-(3-hydroxy-2,2-dimethyl-propyl)benzenesulfonamide

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A mixture of sulphanilyl fluoride (1 g, 5.7 mmol), 3-amino-2,2-dimethylpropan-1-ol (884 mg, 8.6 mmol) and triethylamine (0.876 ml, 6.3 mmol) in butan-1-ol (20 ml) was heated at reflux for 24 hours. The volatiles were removed by evaporation and residue was purified by chromatography on silica gel to give the title compound. NMR: 0.72 (s, 6H), 2.52 (d, 2H), 3.08 (d, 2H), 4.40 (t, 1H), 7.19 (t, 1H), 7.60 (s, 1H), 7.64 (d, 2H), 7.96 (d, 2H), 8.40 (s, 1H), m/z 259 (MN)+.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 24 hours
  3. customThe volatiles were removed by evaporation and residue
  4. customwas purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-d5979c57c8db493db62600cb3367f05e
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06906065B2

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