HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1071575Generated: October 25, 2026
Hydrogen Bromide → 1-(6-Methylpyridin-2-yl)-2-(quinoxalin-6-yl)ethane-1,2-dione
https://huagongshe.com/reaction/1071575
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone | HCID 22394529 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 1-(6-Methylpyridin-2-yl)-2-(quinoxalin-6-yl)ethane-1,2-dione | HCID 22394526 | 86% |
Reaction Steps
A stirred suspension of 6-(2-[6-methylpyridin-2-yl]-acetyl)quinoxaline (1.65 g, 6.3 mmole) in dry DMSO (50 ml) was heated to 70-80° C. (forming a yellow solution) and treated dropwise with aq. HBr (48%, 6 ml). After 2 h the solution was cooled, poured over ice-water and brought to pH 10 with K2CO3. Extraction with EtOAc (3×), drying over Na2SO4, filtration and concentration to dryness in vacuo gave the title compound as a crimson oil (1.5 g, 86%). m/z [ESMS]: 278 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06906089B2 |
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| Source dataset | uspto-grants-2005_06 |
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| ORD ID | ord-77e653f553c4491b8d583a6a99198649 |
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| Source note | uspto-grants-2005_06 |
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