反应详情

温度

75 °C

A stirred suspension of 6-(2-[6-methylpyridin-2-yl]-acetyl)quinoxaline (1.65 g, 6.3 mmole) in dry DMSO (50 ml) was heated to 70-80° C. (forming a yellow solution) and treated dropwise with aq. HBr (48%, 6 ml). After 2 h the solution was cooled, poured over ice-water and brought to pH 10 with K2CO3. Extraction with EtOAc (3×), drying over Na2SO4, filtration and concentration to dryness in vacuo gave the title compound as a crimson oil (1.5 g, 86%). m/z [ESMS]: 278 [M+H]+.

1. customforming a yellow solution) and
2. temperatureAfter 2 h the solution was cooled
3. extractionExtraction with EtOAc (3×)
4. dry with materialdrying over Na2SO4, filtration and concentration to dryness in vacuo