Aniline → Benzamide

HRID 1071582Notes

Reaction equation

HRID 1071582 reaction equation
NC1C=CC=CC=1.N[C:9]1[CH:10]=[C:11]([CH:23]=[CH:24][C:25]=1OC)[C:12]([NH:14]C1C=CC(F)=C(F)C=1)=[O:13]>>[C:12]([NH2:14])(=[O:13])[C:11]1[CH:23]=[CH:24][CH:25]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 10755041HCID 10755041, compound

Product 1

HCID 2331BenzamideYield 32.6%

Procedure

The title compound was synthesized in the same manner as Example 1 using aniline (0.59 g, 6.4 mmol), CSI (0.67 mL, 7.7 mmol), and 3-amino-N-(3,4-difluoro-phenyl)-4-methoxy-benzamide (1.19 g, 4.3 mmol) to give 0.17 g of pure benzamide, N-(3,4-difluorophenyl)-4-methoxy-3-[[[[(phenylamino)carbonyl]amino]sulfonyl]amino]-. Microanalysis: C21H18F2N4O5S; calculated: C=52.94; H=3.81; N=11.76. found: C=52.70; H=4.04; N=11.51. MS: M++1=477 Da.

Sources & evidence

ORD record
ord-eb5cdfb487f54f0aa562dd887951dda5
Source dataset
uspto-grants-2005_06
Patent number
US06906094B2

Reaction notes

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