Acetone → Benzamide

3-Amino-N-(3,4-difluoro-phenyl)-4-methoxy-benzamide (3.0 g, 10.8 mmol) was dissolved in 200 mL dichloromethane and added dropwise to a solution of CSI (1.15 mL, 12.9 mmol) in 50 mL of dichloromethane at 0° C. The resulting white suspension was stirred for 1 hour and then filtered to give 2.94 g of a chlorosulfonyl urea intermediate. This intermediate (1.4 g, 3.5 mmol) was added in portions to a solution of p-anisidine (0.43 g, 3.5 mmol) in 50 mL acetone with triethylamine (1.94 mL, 13.9 mmol). The resulting mixture was stirred for 16 hours at room temperature. The reaction mixture was concentrated in vacuo, and the residue was partitioned between ethyl acetate and 1 M HCl. The ethyl acetate layer was dried over magnesium sulfate, filtered, and concentrated to give a pale pink oily solid. Recrystallization from dichloromethane gave 0.55 g of pure benzamide, N-(3,4-difluorophenyl)-4-methoxy-3-[[[[[(4-methoxyphenyl)amino]-sulfonyl]amino]carbonyl]amino]-. Microanalysis: C22H20F2N4O6S; calculated: C=52.17; H=3.98; N=11.06. found: C=52.20; H=4.06; N=10.98. MS: M++1=507 Da.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe residue was partitioned between ethyl acetate and 1 M HCl
3. dry with materialThe ethyl acetate layer was dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customto give a pale pink oily solid
7. customRecrystallization from dichloromethane

ORD record

ord-de7c8296a22d45fa90732600f3f7951c

Source dataset

uspto-grants-2005_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06906094B2