4-Tert-Butylaniline → Benzamide

HRID 1071586Notes

Reaction equation

HRID 1071586 reaction equation
C(C1C=CC(N)=CC=1)(C)(C)C.N[C:13]1[CH:14]=[C:15]([CH:27]=[CH:28][C:29]=1OC)[C:16]([NH:18]C1C=CC(F)=C(F)C=1)=[O:17]>>[C:16]([NH2:18])(=[O:17])[C:15]1[CH:27]=[CH:28][CH:29]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 698614-Tert-ButylanilineHCID 10755041HCID 10755041, compound

Product 1

HCID 2331BenzamideYield 11.5%

Procedure

The title compound was synthesized as in Example 1 using 4-t-butyl aniline (1.3 mL, 8.1 mmol), CSI (0.85 mL, 9.8 mmol), and 3-amino-N-(3,4-difluoro-phenyl)-4-methoxy-benzamide (1.9 g, 6.8 mmol) to give 0.095 g of benzamide, N-(3,4-difluorophenyl)-3-[[[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]sulfonyl]amino]-4-methoxy-. Microanalysis: C25H26F2N4O5S.0.46 H2O; calculated: C=55.52; H=5.02; N=10.36. found: C=55.46; H=4.94; N=10.40. MS: M++1=533 Da. Mp 199-202° C.

Sources & evidence

ORD record
ord-8310ba4c3ff64433a3ddeead5b2d3891
Source dataset
uspto-grants-2005_06
Patent number
US06906094B2

Reaction notes

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