4-Tert-Butylaniline → Benzamide

Participants

Reaction Steps

The title compound was synthesized as in Example 1 using 4-t-butyl aniline (1.3 mL, 8.1 mmol), CSI (0.85 mL, 9.8 mmol), and 3-amino-N-(3,4-difluoro-phenyl)-4-methoxy-benzamide (1.9 g, 6.8 mmol) to give 0.095 g of benzamide, N-(3,4-difluorophenyl)-3-[[[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]sulfonyl]amino]-4-methoxy-. Microanalysis: C25H26F2N4O5S.0.46 H2O; calculated: C=55.52; H=5.02; N=10.36. found: C=55.46; H=4.94; N=10.40. MS: M++1=533 Da. Mp 199-202° C.

Provenance & Evidence