3-Chloroaniline → Benzamide

HRID 1071588Notes

Reaction equation

HRID 1071588 reaction equation
ClC1C=C(C=CC=1)N.N[C:10]1[CH:11]=[C:12]([CH:24]=[CH:25][C:26]=1OC)[C:13]([NH:15]C1C=CC(F)=C(F)C=1)=[O:14]>>[C:13]([NH2:15])(=[O:14])[C:12]1[CH:24]=[CH:25][CH:26]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 79323-ChloroanilineHCID 10755041HCID 10755041, compound

Product 1

HCID 2331BenzamideYield 5%

Procedure

The title compound was synthesized as in Example 1 using 3-chloroaniline (2.0 mL, 18.9 mmol), CSI (2.0 mL, 23.0 mmol), and 3-amino-N-(3,4difluoro-phenyl)-4-methoxy-benzamide (1.39 g, 5.0 mmol) to give 0.030 g of benzamide, 3-[[[[[(3-chlorophenyl)amino]carbonyl]amino]sulfonyl]amino]-N-(3,4-difluorophenyl)-4-methoxy-. Microanalysis: C21H17ClF2N4O5S; calculated: C=49.37; H=3.35; N=10.97. found: C=48.97; H=3.11; N=10.78. MS: M++1=511 Da. Mp 193-196° C.

Sources & evidence

ORD record
ord-e378cd4739f542b9ac60a619f7f799b1
Source dataset
uspto-grants-2005_06
Patent number
US06906094B2

Reaction notes

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