Benzenamine, 3,5-bis(trifluoromethyl)- → Benzamide

HRID 1071589Notes

Reaction equation

HRID 1071589 reaction equation
FC(F)(F)C1C=C(C=C(C(F)(F)F)C=1)N.N[C:17]1[CH:18]=[C:19]([CH:31]=[CH:32][C:33]=1OC)[C:20]([NH:22]C1C=CC(F)=C(F)C=1)=[O:21]>>[C:20]([NH2:22])(=[O:21])[C:19]1[CH:31]=[CH:32][CH:33]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 10755041HCID 10755041, compound

Product 1

HCID 2331BenzamideYield 11.5%

Procedure

The title compound was synthesized as in Example 1 using 3,5-bis(trifluoromethyl)aniline (1.3 mL, 8.2 mmol), CSI (0.85 mL, 9.8 mmol), and 3-amino-N-(3,4-difluorophenyl)-4-methoxy-benzamide (0.63 g, 2.3 mmol) to give 0.032 g of benzamide, 3-[[[[[[3,5-bis(trifluoromethyl)phenyl]amino]-carbonyl]amino]sulfonyl]amino]-N-(3,4-difluorophenyl)-4-methoxy-. Microanalysis: C23H16F8N4O5S.1.63 H2O; calculated: C=43.04; H=3.02; N=8.73. found: C=43.05; H=2.68; N=8.55. MS: M+−1=611 Da. Mp 175-178° C.

Sources & evidence

ORD record
ord-04fb56ad9da14c889306bcc79928d1e9
Source dataset
uspto-grants-2005_06
Patent number
US06906094B2

Reaction notes

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