3-(Trifluoromethyl)aniline → Benzamide

HRID 1071590Notes

Reaction equation

HRID 1071590 reaction equation
FC(F)(F)C1C=C(C=CC=1)N.N[C:13]1[CH:14]=[C:15]([CH:27]=[CH:28][C:29]=1OC)[C:16]([NH:18]C1C=CC(F)=C(F)C=1)=[O:17]>>[C:16]([NH2:18])(=[O:17])[C:15]1[CH:27]=[CH:28][CH:29]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 10755041HCID 10755041, compound

Product 1

HCID 2331BenzamideYield 15%

Procedure

The title compound was synthesized as in Example 1 using 3-trifluoromethylaniline (1.32 g, 10.6 mmol), CSI (0.85 mL, 9.8 mmol), and 3-amino-N-(3,4-difluoro-phenyl)-4-methoxy-benzamide (0.92 g, 3.3 mmol) to give 0.060 g of benzamide, N-(3,4-difluorophenyl)-4-methoxy-3-[[[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]sulfonyl]amino]-. Microanalysis: C22H17F5N4O5S; calculated: C=48.53; H=3.15; N=10.29. found: C=48.52; H=3.09; N=10.18. MS: M++1=545 Da. Mp 198-200° C.

Sources & evidence

ORD record
ord-c47e025f1cfb4242b3a0afc62f32df5f
Source dataset
uspto-grants-2005_06
Patent number
US06906094B2

Reaction notes

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