HCID 22393638, compound → HCID 22393627, compound

HRID 1071643Notes

Reaction equation

HRID 1071643 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][C:17]([C:27]#[N:28])([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:18]([CH3:20])[CH3:19])[CH2:10][CH:9]1[C:29]([O:31][CH2:32][CH3:33])=[O:30])C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[C:27]([C:17]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([CH:18]([CH3:20])[CH3:19])[CH2:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][NH:8][CH:9]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH2:10]1)#[N:28]

Participants

5

Reactant 2

HCID 22393638HCID 22393638, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22393627HCID 22393627, compoundYield 93.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Ethyl 1-benzyl-4-(4-cyano-5-methyl-4-phenylhexyl)-2-piperazinecarboxylate (857 mg) was dissolved in ethanol (15 ml), and 770 mg of 10% Pd-C was added. After replacing the atmosphere with hydrogen, the mixture was stirred. After completion of the reaction, the solution was evaporated, to give 639 mg (93%) of the title compound as a crude product.

Workup

  1. customAfter completion of the reaction
  2. customthe solution was evaporated

Sources & evidence

ORD record
ord-190f5bf963a247468fa3d30ebb718bc4
Source dataset
uspto-grants-2005_06
Patent number
US06906072B1

Reaction notes

Loading…