HCID 22393753, compound → HCID 22393725, compound

HRID 1071644Notes

Reaction equation

HRID 1071644 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[CH2:10][CH:9]1[C:24]([O:26][CH2:27][CH3:28])=[O:25])C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[F:23][C:20]1[CH:19]=[CH:18][C:17]([O:16][CH2:15][CH2:14][N:11]2[CH2:12][CH2:13][NH:8][CH:9]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:10]2)=[CH:22][CH:21]=1

Participants

5

Reactant 2

HCID 22393753HCID 22393753, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22393725HCID 22393725, compoundYield 100.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Ethyl 1-benzyl-4-[2-(4-fluorophenoxy)ethyl)-2-piperazinecarboxylate (977 mg) synthesized in accordance with Example 241 described later was dissolved in ethanol (15 ml), and 210 mg of 10% Pd-C was added. After replacing the atmosphere with hydrogen, the mixture was stirred. After completion of the reaction, the solution was evaporated, to give 752 mg (100%) of the title compound as a crude product.

Workup

  1. customAfter completion of the reaction
  2. customthe solution was evaporated

Sources & evidence

ORD record
ord-4c2611acee6b4e54895930a89b81b54c
Source dataset
uspto-grants-2005_06
Patent number
US06906072B1

Reaction notes

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