α-(3-Iodopropyl)-α-(1-methylethyl)-2-thiopheneacetonitrile → 1-[4-Cyano-4-(2-thienyl)-5-methylhexyl]-4-[2-(6-fluoromethyl-2-pyridyloxy)ethyl]piperazine
Reaction equation
[C:1]([C:3]([C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)([CH:8]([CH3:10])[CH3:9])[CH2:4][CH2:5][CH2:6]I)#[N:2].[F:16][CH2:17][C:18]1[N:23]=[C:22]([O:24][CH2:25][CH2:26][N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH:21]=[CH:20][CH:19]=1>>[C:1]([C:3]([C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)([CH:8]([CH3:10])[CH3:9])[CH2:4][CH2:5][CH2:6][N:30]1[CH2:31][CH2:32][N:27]([CH2:26][CH2:25][O:24][C:22]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:17][F:16])[N:23]=2)[CH2:28][CH2:29]1)#[N:2]Participants
3
Procedure
The title compound was synthesized in accordance with Example 75 from 4-cyano-4-(2-thienyl)-5-methylhexyl iodide and 1-[2-(6-fluoromethyl-2-pyridyloxy)ethyl]piperazine. The physico-chemical data of the compound was as below.
Sources & evidence
- ORD record
- ord-048f54def6fe4896ac58c0a05945aa87
- Source dataset
- uspto-grants-2005_06
- Patent number
- US06906072B1
Reaction notes
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