Toluene → HCID 68561724, compound

HRID 1071688Notes

Reaction equation

HRID 1071688 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH2:14][C:15]1[CH:19]=[C:18]([C:20]3[S:21][C:22]([Cl:25])=[CH:23][CH:24]=3)[O:17][N:16]=1)[C:9]([C:26]([O:28]C(C)(C)C)=[O:27])=[CH:8]2)=[O:4].C1(C)C=CC=CC=1>FC(F)(F)C(O)=O>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH2:14][C:15]1[CH:19]=[C:18]([C:20]3[S:21][C:22]([Cl:25])=[CH:23][CH:24]=3)[O:17][N:16]=1)[C:9]([C:26]([OH:28])=[O:27])=[CH:8]2)=[O:4]

Participants

4

Reactant 2

HCID 1140TolueneHCID 68560299HCID 68560299, compound

Product 1

HCID 68561724HCID 68561724, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

9.5 g 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester were dissolved in 300 ml trifluoro-acetic acid and stirred for 1 h at RT. Then 200 ml toluene were added and the solvents were removed under reduced pressure. This procedure was repeated three times, then the residue was dried in vacuo. Yield: 8.4 g.

Workup

  1. customthe solvents were removed under reduced pressure
  2. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-88d31d289db348afac08bd0f88b656cf
Source dataset
uspto-grants-2005_06
Patent number
US06906084B2

Reaction notes

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