Hydrochloric Acid → HCID 22394348, compound

Participants

Reaction Steps

To a solution of 1.45 g 1-[(4-chloro-phenylcarbamoyl)-methyl]-1H-indole-2-carboxylic acid ethyl ester in 100 ml tetrahydrofuran 30 ml water and 0.59 g potassium hydroxide were added. After stirring for 2 hours at room temperature the reaction mixture was acidified with 6 N hydrochloric acid. The precipitate was collected by filtration and was washed with 20 ml water. The product was obtained as a white solid which was dried under reduced pressure.

Provenance & Evidence