Hydrochloric Acid → HCID 22394348, compound

HRID 1071694Notes

Reaction equation

HRID 1071694 reaction equation
C([O:3][C:4]([C:6]1[N:7]([CH2:15][C:16](=[O:25])[NH:17][C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:5])C.[OH-].[K+].Cl>O1CCCC1>[Cl:24][C:21]1[CH:20]=[CH:19][C:18]([NH:17][C:16]([CH2:15][N:7]2[C:8]3[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH:14]=[C:6]2[C:4]([OH:5])=[O:3])=[O:25])=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 68856627HCID 68856627, compound

Product 1

HCID 22394348HCID 22394348, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 1.45 g 1-[(4-chloro-phenylcarbamoyl)-methyl]-1H-indole-2-carboxylic acid ethyl ester in 100 ml tetrahydrofuran 30 ml water and 0.59 g potassium hydroxide were added. After stirring for 2 hours at room temperature the reaction mixture was acidified with 6 N hydrochloric acid. The precipitate was collected by filtration and was washed with 20 ml water. The product was obtained as a white solid which was dried under reduced pressure.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwas washed with 20 ml water
  3. customThe product was obtained as a white solid which
  4. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-8d0a8c88502d4c6bae56ca5a5fc48c77
Source dataset
uspto-grants-2005_06
Patent number
US06906084B2

Reaction notes

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