Hydrochloric Acid → HCID 20801181, compound

HRID 1071695Notes

Reaction equation

HRID 1071695 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11]([C:13]2[N:14]([CH2:25][C:26]3[CH:30]=[C:29]([C:31]4[S:32][C:33]([Cl:36])=[CH:34][CH:35]=4)[O:28][N:27]=3)[C:15]3[C:20]([CH:21]=2)=[CH:19][C:18]([N+:22]([O-])=O)=[CH:17][CH:16]=3)=[O:12])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].O.O.[Sn](Cl)(Cl)(Cl)[Cl:40].Cl.[OH-].[Na+]>C(O)C>[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11]([C:13]2[N:14]([CH2:25][C:26]3[CH:30]=[C:29]([C:31]4[S:32][C:33]([Cl:36])=[CH:34][CH:35]=4)[O:28][N:27]=3)[C:15]3[C:20]([CH:21]=2)=[C:19]([Cl:40])[C:18]([NH2:22])=[CH:17][CH:16]=3)=[O:12])[CH2:6][CH2:5]1)([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 10239497HCID 10239497, compoundHCID 85782573Tin tetrachloride dihydrate

Product 1

HCID 20801181HCID 20801181, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

24.4 mg 1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-nitro-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide were added to a solution of 58.5 mg tin chloride dihydrate in 1 ml ethanol. 0.5 ml 12 N aqueous hydrochloric acid was added and the mixture was stirred at room temperature for 16 hours. After cooling of the reaction mixture it was basified to pH 12 with saturated aqueous solution of sodium hydroxide and the product isolated by filtration. The product was obtained as a white solid which was dried under reduced pressure.

Workup

  1. temperatureAfter cooling of the reaction mixture it
  2. customthe product isolated by filtration
  3. customThe product was obtained as a white solid which
  4. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-0b078de4343849a59468234341fa22b3
Source dataset
uspto-grants-2005_06
Patent number
US06906084B2

Reaction notes

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