Diisopropylethylamine → HCID 69747047, compound

HRID 1071827Notes

Reaction equation

HRID 1071827 reaction equation
F[C:2](F)(F)C([O-])=O.[CH2:8]([C@H:15]([NH2:24])[C@@H:16]([OH:23])[C@@H:17]([OH:22])[CH2:18][CH2:19][CH2:20][CH3:21])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH3:25][C:26]1[CH:27]=[C:28]([CH:32]=[C:33]([C:35]([N:37]([CH2:41][CH2:42][CH3:43])[CH2:38][CH2:39][CH3:40])=[O:36])[CH:34]=1)[C:29](O)=[O:30].CCN(C(C)C)C(C)C>>[CH2:8]([C@H:15]([NH:24][C:29](=[O:30])[C:28]1[CH:27]=[C:26]([CH3:25])[CH:34]=[C:33]([C:35]([N:37]([CH2:41][CH2:42][CH3:43])[CH2:38][CH2:39][CH3:40])=[O:36])[CH:32]=1)[C@@H:16]([OH:23])[C@@H:17]([OH:22])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:2])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

5

Reactant 4

HCID 81531DiisopropylethylamineHCID 84468TrifluoroacetateHCID 113913935-methyl-N,N-dipropylisophthalamic acidHCID 59067290HCID 59067290, compound

Product 1

HCID 69747047HCID 69747047, compound

Procedure

The trifluoroacetate salt of (1S,2R,3S)-1-benzyl-2,3-dihydroxyheptylamine (0.1 mmol) was reacted with 3-methyl-5-[(dipropylamino)carbonyl]benzoic acid as described in method A (addition of an extra equivalent of DIEA to neutralize the amine salt) to give N1-[(1S,2R,3S)-1-benzyl-2,3-dihydroxy-octyl]-5-methyl-N3,N3-dipropyl-isophthalamide. MS (ESI+) for C29H42N2O4 m/z 483 (M+H)+.

Sources & evidence

ORD record
ord-eb538da7f641443194054d14628ea916
Source dataset
uspto-grants-2005_06
Patent number
US06906104B2

Reaction notes

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