HCID 22390615, compound → HCID 22390586, compound

HRID 1071943Notes

Reaction equation

HRID 1071943 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH3:18])[S:6]([C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1)(=[O:8])=[O:7]>C(O)C.[Pd]>[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH3:18])[S:6]([C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=1)(=[O:8])=[O:7]

Participants

4

Reactant 1

HCID 22390615HCID 22390615, compound

Product 1

HCID 22390586HCID 22390586, compoundYield 92.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

N-(2-Methoxyethyl)-N-methyl-4-nitrobenzenesulphonamide (Method 10; 3.88 g) was reduced by hydrogenation in ethanol (100 ml) over 10% palladium on carbon (400 mg) at 3 bar pressure. The catalyst was removed by filtration and the volatiles evaporated to give the title compound (3.2 g). M/z: 245.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe volatiles evaporated

Sources & evidence

ORD record
ord-a01c1a0d0b7b4a668ebb52c37ea00c7f
Source dataset
uspto-grants-2005_06
Patent number
US06908920B2

Reaction notes

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