Chloropyrazine → HCID 69588378, compound

Temperature

110 °C

A solution of 2-chloropyrazine (26.12 g, 228.0 mmol) and cyclobutylamine (40.00 mL, 468.5 mmol) was heated in a pressure reaction flask with stirring to 110° C. for 16 hours. The brown reaction was allowed to cool to room temperature and was diluted with water (750 mL). The aqueous solution was extracted with ethyl acetate (2×250 mL). The combined organic solutions were washed with water (1×250 mL), saturated NaHCO3 (1×250 mL) and brine (2×250 mL). The organic solution was dried (MgSO4), filtered, and concentrated. The crude product was purified by MPLC (20% ethyl acetate-40% ethyl acetate/hexanes) to afford N-cyclobutylaminopyrazine (EX-115A) in 93% yield: 1H NMR (300 MHz, DMSO) δ 7.97-7.96 (m, 1H) 7.82-7.79 (m, 2H), 5.12 (br s, 1H), 430-4.18 (m, 1H) 2.51-2.39 (m, 2H), 1.97-1.73 (m, 4H); 13C NMR (75 MHz, DMSO) δ 149.3, 137.6, 128.3, 126.9, 42.2, 26.7, 10.7; HRMS (ES) calcd for C8H12N3 150.1031, found 150.0992.

1. customThe brown reaction
2. temperatureto cool to room temperature
3. extractionThe aqueous solution was extracted with ethyl acetate (2×250 mL)
4. washThe combined organic solutions were washed with water (1×250 mL), saturated NaHCO3 (1×250 mL) and brine (2×250 mL)
5. dry with materialThe organic solution was dried (MgSO4)
6. filtrationfiltered
7. concentrationconcentrated
8. customThe crude product was purified by MPLC (20% ethyl acetate-40% ethyl acetate/hexanes)

ORD record

ord-64b6ee11c9c6424f95c34816afd10218

Source dataset

uspto-grants-2005_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06908919B2