4-(2-Azidoethyl)benzamide → HCID 12666304, compound

HRID 1071972Notes

Reaction equation

HRID 1071972 reaction equation
[N:1]([CH2:4][CH2:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([NH2:12])=[O:11])=[CH:8][CH:7]=1)=[N+]=[N-].[H][H]>CCO.[Pd]>[NH2:1][CH2:4][CH2:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([NH2:12])=[O:11])=[CH:8][CH:7]=1

Participants

5

Reactant 2

HCID 223906894-(2-Azidoethyl)benzamideHCID 178418361HCID 178418361, compound

Product 1

HCID 12666304HCID 12666304, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Pd/C (11 mg, 0.11 mmol) was added to a solution of 4-(2-azidoethyl)benzamide (200 mg, 1.05 mmol) in EtOH (4 mL). A hydrogen balloon was placed over the reaction and it stirred for about four hours. The crude reaction was filtered through a pad of celite and concentrated to give 4-(2-aminoethyl)benzamide which was used without further purification.

Workup

  1. customThe crude reaction
  2. filtrationwas filtered through a pad of celite
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-725358ff78ba474c82463404105b2143
Source dataset
uspto-grants-2005_06
Patent number
US06908921B2

Reaction notes

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