Phosphorus oxychloride → 2-Chloro-4-methyl-5-nitropyridine

HRID 1071983Notes

Reaction equation

HRID 1071983 reaction equation
O[C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.O=P(Cl)(Cl)[Cl:14]>>[Cl:14][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178429283HCID 178429283, compound

Product 1

HCID 3453642-Chloro-4-methyl-5-nitropyridine

Conditions

Temperature
100 °C

Procedure

22.3 g of 2-hydroxy-4-methyl-5-nitropyridine and 170 ml of POCl3 are mixed together and heated at 100° C. for 3 hours. The cooled reaction medium is poured onto ice to yield a beige precipitate of 2-chloro-4-methyl-5-nitropyridine.

Workup

  1. customThe cooled reaction medium
  2. additionis poured onto ice

Sources & evidence

ORD record
ord-4137dcf5574f483eb65783e0b5a270d8
Source dataset
uspto-grants-2005_06
Patent number
US06908922B2

Reaction notes

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