反应详情

A solution of the product of Step A (9.33 g) in ether (42 mL) was treated with bromine (2.1 mL) and the mixture stirred for approximately 17 hours. The mixture was slowly poured into saturated sodium bicarbonate solution (100 mL) and then the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (100 mL). The combined organic layers were washed with a fresh portion of water (100 mL), dried over magnesium sulfate, filtered and evaporated to give the title compound (11 g).

1. customthe organic layer was separated
2. washThe aqueous layer was washed with a fresh portion of ether (100 mL)
3. washThe combined organic layers were washed with a fresh portion of water (100 mL)
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customevaporated