反应详情

The title compound (47% yield) was prepared from 5-(4-chloro-6-oxo-6,7-dihydro-pyrrolo[2,3-d]pyrimidin-5-ylidenemethyl)-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide and 1-methylpiperazine according to the procedure described for Example 14. 1H NMR (300 MHz, DMSO-d6) δ 13.37 (br s, 1H, NH), 11.83 (br s, 1H, NH), 10.56 (v br s, 1H), 8.45 (v br s, 1H), 8.38 (s, 1H, H-vinyl), 7.09 (s, 1H), 6.87 (s, 1H), 3.4-3.6 (m, 10H, 5×CH2), 2.85 (m, 4H, 2×CH2), 2.4-2.6 (m, 6H, 3×CH2), 2.49 (under DMSO, 3H, CH3), 2.31 (s, 3H, CH3). MS 481.3 [M++1].