反应详情

A mixture of 4-chloro-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (169 mg, 1 mmol), 3-methyl-5-(morpholine-4-carbonyl)-1H-pyrrole-2-carbaldehyde (222 mg, 1 mmol) and piperidine (2 drops) in ethanol (3 mL) was heated to reflux for overnight. The precipitate was collected by vacuum filtration, washed with ethyl acetate/hexane and dried to give 332.2 mg (79%) of the title compound as a yellow solid. MS 423 [M++1].

1. temperaturewas heated
2. temperatureto reflux for overnight
3. filtrationThe precipitate was collected by vacuum filtration
4. washwashed with ethyl acetate/hexane
5. customdried