Methanol → 1-(Pyridin-3-yl)ethan-1-amine

3-Acetylpyridine (2.4 g, 20 mmol, Aldrich) was dissolved in 2M ammonia solution in methyl alcohol (50 mL, 100 mmol, Aldrich) and acetic acid (15 mL, J. T. Baker) was slowly added at 0 C. After stirring for 3 h at room temperature, the sodium cyanoborohydride (5.0 g, 80 mmol, Aldrich) was added to the solution at 0 C. The mixture was stiffed under nitrogen at room temperature for overnight then the reaction was cooled at ice bath and quenched with aqueous 5 N sodium hydroxide (30 mL, 150 mmol, J. T. Baker). The methyl alcohol was removed from the mixture via vacuo. The residue was extracted by diethyl ether (30 mL×4). The combined organic phases were dried over anhydrous magnesium sulfate and concentrated via vacuo to give crude 1-pyridin-3-yl-ethylamine as light yellow oil in 44% yield (1.07 g, 8.8 mmol).

1. waitThe mixture was stiffed under nitrogen at room temperature for overnight
2. temperaturethe reaction was cooled at ice bath
3. customThe methyl alcohol was removed from the mixture via vacuo
4. extractionThe residue was extracted by diethyl ether (30 mL×4)
5. dry with materialThe combined organic phases were dried over anhydrous magnesium sulfate
6. concentrationconcentrated via vacuo

ORD record

ord-056217341c4f4fdc8430248c83ad897b

Source dataset

uspto-grants-2005_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06908935B2