反应详情

温度

0 °C

The procedure described in Example 13 is followed with the difference that, after the hydrolysis, the reaction mixture is diluted with 3500 ml of water, cooled to 0° C., the precipitated crystalline cetirizine sodium salt is allowed to sediment for 1 hour, filtered, then dissolved in 1000 ml of water, the pH is adjusted to a value of 3.8 by the addition of hydrochloric acid, then the procedure of Example 13 is continued. Thus, 65.7 g (71.2%) of the title compound are obtained. The purity of the product corresponds to the quality requirements given in Eur. Pharm., 3, 1997, 1084.

1. customafter the hydrolysis
2. filtrationfiltered
3. dissolutiondissolved in 1000 ml of water
4. additionthe pH is adjusted to a value of 3.8 by the addition of hydrochloric acid