huagongshe.com
HRID1072355

反应详情

EQUATION

反应方程式

HRID 1072355 的结构方程式

REACTANTS

反应物

2
结构：BrCc1ccccc1
HCID7498

alpha-Bromotoluene

C7H7Br

结构：C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(c3cn4cnc(C(=O)c5cccnc5)c4s3)[C@H](C)[C@H]12
HCID68934911

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(c3cn4cnc(C(=O)c5ccc[n+](Cc6ccccc6)c5)c4s3)[C@H](C)[C@H]12.[Br-]
HCID131725007

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

4-Nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-[7-(pyridin-3-yl)carbonylimidazo[5,1-b]thiazol-2-yl]-1-carbapen-2-em-3-carboxylate (78.1 mg) was suspended in 1.5 ml of acetonitrile to prepare a suspension. Benzyl bromide (0.032 ml) was added to the suspension, and the mixture was stirred at room temperature for 10 hr. The reaction solution was concentrated under the reduced pressure to give 4-nitrobenzyl (1S,5R,6S)-2-[7-(1-benzylpyridinium-3-yl)carbonylimidazo[5,1-b]thiazol-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate bromide.

WORKUP

后处理

  1. customto prepare a suspension
  2. concentrationThe reaction solution was concentrated under the reduced pressure